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Aspirin may reduce liver fibrosis progression: Evidence from a multicenter retrospective study of recurrent hepatitis C after liver transplantation.
- Source :
-
Clinics and research in hepatology and gastroenterology [Clin Res Hepatol Gastroenterol] 2014 Oct; Vol. 38 (5), pp. 570-6. Date of Electronic Publication: 2014 Aug 15. - Publication Year :
- 2014
-
Abstract
- Background and Aims: There is evidence for an association between thrombosis in the hepatic microcirculation and liver fibrosis. The aim of this study was to evaluate the role of daily low-dose aspirin (75 or 100mg, given for prevention of hepatic artery thrombosis) in fibrosis progression to ≥ F2 fibrosis score in liver-transplant recipients with recurrent hepatitis C virus (HCV).<br />Methods: All HCV-positive patients who had undergone liver transplantation (LT) between 2000 and 2010 were included. Exclusion criteria were negative HCV RNA, previous LT or death within a year of LT. Liver fibrosis was assessed by histological evaluation. Data were censored at the date of the last histological evaluation before starting anti HCV therapy. Progression to fibrosis F ≥ 2 was analyzed with a multistate model with time-dependent covariables.<br />Results: One hundred and eighty-eight patients were included. In univariate analysis, older recipient and donor age, male donor gender, activity score ≥ A2 after LT, number of steroid boluses and aspirin intake (HR: 0.75 [0.57-0.97]; P=0.03) influenced the risk of progression to fibrosis ≥ F2. In multivariate analysis, adjusted on site, older donor age, male donor gender, activity score ≥ A2 and number of steroids boluses, remained independent predictors of fibrosis progression, while younger recipient age and aspirin intake (HR: 0.65 [0.47-0.91]; P=0.01) were associated with a slower fibrosis progression.<br />Conclusion: Low-dose aspirin treatment might be associated with a lower risk of liver fibrosis progression in patients with HCV recurrence after LT.<br /> (Copyright © 2014 Elsevier Masson SAS. All rights reserved.)
- Subjects :
- Disease Progression
Female
Humans
Male
Middle Aged
Recurrence
Retrospective Studies
Aspirin therapeutic use
Hepatitis C, Chronic complications
Liver Cirrhosis drug therapy
Liver Cirrhosis etiology
Liver Transplantation
Postoperative Complications drug therapy
Postoperative Complications etiology
Subjects
Details
- Language :
- English
- ISSN :
- 2210-741X
- Volume :
- 38
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Clinics and research in hepatology and gastroenterology
- Publication Type :
- Academic Journal
- Accession number :
- 25130796
- Full Text :
- https://doi.org/10.1016/j.clinre.2014.07.004