Sequential gene silencing using wavelength-selective caged morpholino oligonucleotides.

Authors :: Yamazoe S
Liu Q
McQuade LE
Deiters A
Chen JK
Source :: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2014 Sep 15; Vol. 53 (38), pp. 10114-8. Date of Electronic Publication: 2014 Aug 01.
Publication Year :: 2014
Abstract: Spectrally differentiated caged morpholino oligonucleotides (cMOs) and wavelength-selective illumination have been used to sequentially inactivate organismal gene function. The efficacy of these reverse-genetic chemical probes has been demonstrated in zebrafish embryos, and these reagents have been employed to examine the mechanisms of mesoderm patterning.<br /> (© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Subjects :: Amino Acid Sequence
Animals
Molecular Structure
Morpholinos chemistry
Zebrafish embryology
Gene Silencing
Morpholinos genetics

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