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Clinical decision rules and D-Dimer in venous thromboembolism: current controversies and future research priorities.

Authors :
Rodger MA
Le Gal G
Wells P
Baglin T
Aujesky D
Righini M
Palareti G
Huisman M
Meyer G
Source :
Thrombosis research [Thromb Res] 2014 Oct; Vol. 134 (4), pp. 763-8. Date of Electronic Publication: 2014 Aug 04.
Publication Year :
2014

Abstract

Venous thromboembolism (VTE) is a potentially lethal clinical condition that is suspected in patients with common clinical complaints, in many and varied, clinical care settings. Once VTE is diagnosed, optimal therapeutic management (thrombolysis, IVC filters, type and duration of anticoagulants) and ideal therapeutic management settings (outpatient, critical care) are also controversial. Clinical prediction tools, including clinical decision rules and D-Dimer, have been developed, and some validated, to assist clinical decision making along the diagnostic and therapeutic management paths for VTE. Despite these developments, practice variation is high and there remain many controversies in the use of the clinical prediction tools. In this narrative review, we highlight challenges and controversies in VTE diagnostic and therapeutic management with a focus on clinical decision rules and D-Dimer.<br /> (Copyright © 2014 Elsevier Ltd. All rights reserved.)

Details

Language :
English
ISSN :
1879-2472
Volume :
134
Issue :
4
Database :
MEDLINE
Journal :
Thrombosis research
Publication Type :
Academic Journal
Accession number :
25129416
Full Text :
https://doi.org/10.1016/j.thromres.2014.07.031