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Role of atrial natriuretic Peptide in oxytocin induced cardioprotection.
- Source :
-
Heart, lung & circulation [Heart Lung Circ] 2015 Jan; Vol. 24 (1), pp. 86-93. Date of Electronic Publication: 2014 Jun 30. - Publication Year :
- 2015
-
Abstract
- Background: The purpose of this study was to determine whether endogenous atrial natriuretic peptide (ANP) contributes to the protective effect of neurohypophysial hormone oxytocin (OT) in heart preconditioning.<br />Methods: Sprague-Dawley male rats were subjected to 25 min regional ischaemia and 120 min reperfusion and were divided into eight groups. Oxytocin or an equivalent volume of saline was administrated intraperitoneally, 30 min before ischaemia. The OT receptor antagonist (atosiban), ANP receptor antagonist (anantin) and nitric oxide synthase inhibitor (L-NAME) were injected 10 min before OT. In other groups, atosiban, anantin and L-NAME were only administered 40 min prior to ischaemia.<br />Results: Compared with the ischaemia/reperfusion group (I/R), alterations in infarct size, biochemical parameters [LDH (lactate dehydrogenase), CK-MB (creatine kinase-MB), MDA (malondialdehyde) plasma levels] and severity of ventricular arrhythmia due to I/R injury were attenuated and VF was abolished by OT treatment. These OT effects were eliminated by OT and ANP receptor blockers and nitric oxide synthase inhibitor, but anantin did not reverse the effect of OT in lipid peroxidation.<br />Conclusions: These findings demonstrate an important contributory role of ANP in the OT induced protection in myocardial ischaemia reperfusion. OT also reduced lipid peroxidation with a NO-dependent mechanism.<br /> (Copyright © 2014 Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ). Published by Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Enzyme Inhibitors pharmacology
Hormone Antagonists pharmacology
Lipid Peroxidation drug effects
Male
Myocardial Infarction metabolism
Myocardial Reperfusion Injury metabolism
NG-Nitroarginine Methyl Ester pharmacology
Oxytocics pharmacology
Peptides, Cyclic pharmacology
Rats
Rats, Sprague-Dawley
Vasotocin analogs & derivatives
Vasotocin pharmacology
Atrial Natriuretic Factor metabolism
Cardiotonic Agents pharmacology
Myocardial Infarction prevention & control
Myocardial Reperfusion Injury prevention & control
Oxytocin pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1444-2892
- Volume :
- 24
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Heart, lung & circulation
- Publication Type :
- Academic Journal
- Accession number :
- 25126708
- Full Text :
- https://doi.org/10.1016/j.hlc.2014.05.023