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N-acetylglucosamine enhances survival ability of tilapias infected by Streptococcus iniae.
- Source :
-
Fish & shellfish immunology [Fish Shellfish Immunol] 2014 Oct; Vol. 40 (2), pp. 524-30. Date of Electronic Publication: 2014 Aug 10. - Publication Year :
- 2014
-
Abstract
- Streptococcus iniae infection has emerged as a serious fish health and economic problem in the global aquaculture operations. Current antibiotic options are few and possess severe practical limitations and potential adverse environmental impacts. The major factor contributing to the large burden of S. iniae disease in aquaculture is the lack of fundamental knowledge of innate immunity against the pathogen. In the present study, we use a tilapia model to explore which metabolites are crucial for the defense against the infection caused by S. iniae. We establish GC/MS based metabolic profile of tilapia liver and then compare the metabolic difference between survivals and the dying fish post the bacterial infection. We identify elevating N-acetylglucosamine in survival group as the most crucial metabolite differentiating the survivals from the dying in these fish infected by S. iniae. Exogenous N-acetylglucosamine significantly elevates survival ability of tilapia against the infection caused by S. iniae. Our findings highlight the importance of metabolic strategy against bacterial infections.<br /> (Copyright © 2014 Elsevier Ltd. All rights reserved.)
- Subjects :
- Adjuvants, Immunologic pharmacology
Animals
Fish Diseases microbiology
Fish Diseases mortality
Gas Chromatography-Mass Spectrometry
Streptococcal Infections immunology
Streptococcal Infections microbiology
Streptococcal Infections mortality
Streptococcus physiology
Survival Analysis
Acetylglucosamine pharmacology
Fish Diseases immunology
Immunity, Innate drug effects
Metabolome
Streptococcal Infections veterinary
Tilapia genetics
Tilapia metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1095-9947
- Volume :
- 40
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Fish & shellfish immunology
- Publication Type :
- Academic Journal
- Accession number :
- 25120218
- Full Text :
- https://doi.org/10.1016/j.fsi.2014.08.008