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An insight into the gastrointestinal component of fibromyalgia: clinical manifestations and potential underlying mechanisms.
- Source :
-
Rheumatology international [Rheumatol Int] 2015 Mar; Vol. 35 (3), pp. 433-44. Date of Electronic Publication: 2014 Aug 14. - Publication Year :
- 2015
-
Abstract
- Fibromyalgia syndrome is characterized by chronic generalized pain accompanied by a broad symptomatologic spectrum. Besides chronic fatigue, sleep disturbances, headaches and cognitive dysfunction that are extensively described in the literature, a considerable proportion of patients with fibromyalgia experience gastrointestinal symptoms that are commonly overlooked in the studies that are not specifically dedicated to evaluate these manifestations. Nevertheless, various attempts were undertaken to explore the gastrointestinal dimension of fibromyalgia. Several studies have demonstrated an elevated comorbidity of irritable bowel syndrome (IBS) among patients with fibromyalgia. Other studies have investigated the frequency of presentation of gastrointestinal symptoms in fibromyalgia in a nonspecific approach describing several gastrointestinal complaints frequently reported by these patients such as abdominal pain, dyspepsia and bowel changes, among others. Several underlying mechanisms that require further investigation could serve as potential explanatory hypotheses for the appearance of such manifestations. These include sensitivity to dietary constituents such as gluten, lactose or FODMAPs or alterations in the brain-gut axis as a result of small intestinal bacterial overgrowth or subclinical enteric infections such as giardiasis. The gastrointestinal component of fibromyalgia constitutes a relevant element of the multidisciplinary pathophysiologic mechanisms underlying fibromyalgia that need to be unveiled, as this would contribute to the adequate designation of relevant treatment alternatives corresponding to these manifestations.
- Subjects :
- Celiac Disease complications
Disaccharides
Fermentation
Fibromyalgia complications
Food Hypersensitivity complications
Gastrointestinal Diseases complications
Gastrointestinal Diseases physiopathology
Humans
Irritable Bowel Syndrome complications
Lactose Intolerance complications
Monosaccharides
Oligosaccharides
Celiac Disease physiopathology
Fibromyalgia physiopathology
Food Hypersensitivity physiopathology
Irritable Bowel Syndrome physiopathology
Lactose Intolerance physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1437-160X
- Volume :
- 35
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Rheumatology international
- Publication Type :
- Academic Journal
- Accession number :
- 25119830
- Full Text :
- https://doi.org/10.1007/s00296-014-3109-9