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Tannic acid modified silver nanoparticles show antiviral activity in herpes simplex virus type 2 infection.
- Source :
-
PloS one [PLoS One] 2014 Aug 12; Vol. 9 (8), pp. e104113. Date of Electronic Publication: 2014 Aug 12 (Print Publication: 2014). - Publication Year :
- 2014
-
Abstract
- The interaction between silver nanoparticles and herpesviruses is attracting great interest due to their antiviral activity and possibility to use as microbicides for oral and anogenital herpes. In this work, we demonstrate that tannic acid modified silver nanoparticles sized 13 nm, 33 nm and 46 nm are capable of reducing HSV-2 infectivity both in vitro and in vivo. The antiviral activity of tannic acid modified silver nanoparticles was size-related, required direct interaction and blocked virus attachment, penetration and further spread. All tested tannic acid modified silver nanoparticles reduced both infection and inflammatory reaction in the mouse model of HSV-2 infection when used at infection or for a post-infection treatment. Smaller-sized nanoparticles induced production of cytokines and chemokines important for anti-viral response. The corresponding control buffers with tannic acid showed inferior antiviral effects in vitro and were ineffective in blocking in vivo infection. Our results show that tannic acid modified silver nanoparticles are good candidates for microbicides used in treatment of herpesvirus infections.
- Subjects :
- Animals
Antiviral Agents chemistry
Cell Line
Chlorocebus aethiops
Cytokines metabolism
Disease Models, Animal
Dose-Response Relationship, Drug
Female
Herpes Simplex metabolism
Inflammation drug therapy
Inflammation metabolism
Inflammation virology
Metal Nanoparticles ultrastructure
Mice
Microbial Sensitivity Tests
Virus Attachment drug effects
Virus Internalization drug effects
Antiviral Agents pharmacology
Herpes Simplex drug therapy
Herpes Simplex virology
Herpesvirus 2, Human drug effects
Metal Nanoparticles administration & dosage
Metal Nanoparticles chemistry
Silver chemistry
Silver pharmacology
Tannins chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1932-6203
- Volume :
- 9
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- PloS one
- Publication Type :
- Academic Journal
- Accession number :
- 25117537
- Full Text :
- https://doi.org/10.1371/journal.pone.0104113