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Strategies for targeting the androgen receptor axis in prostate cancer.

Authors :
Carver BS
Source :
Drug discovery today [Drug Discov Today] 2014 Sep; Vol. 19 (9), pp. 1493-7. Date of Electronic Publication: 2014 Aug 10.
Publication Year :
2014

Abstract

Androgen receptor (AR) signaling plays a critical role in prostate cancer cell proliferation, survival, and differentiation. Therapeutic strategies targeting the androgen receptor have been developed for the treatment of metastatic hormone-naïve prostate cancer; however, despite effective targeting recent studies have demonstrated that during progression to a castrate-resistant phenotype there is restoration of AR target gene expression. On the basis of this observation, second-generation therapeutics have been developed to target AR in the castrate-resistant setting resulting in a survival benefit. In this review we will discuss the mechanisms promoting AR signaling and the development of second-generation therapeutics targeting AR in castrate-resistant prostate cancer.<br /> (Copyright © 2014 Elsevier Ltd. All rights reserved.)

Details

Language :
English
ISSN :
1878-5832
Volume :
19
Issue :
9
Database :
MEDLINE
Journal :
Drug discovery today
Publication Type :
Academic Journal
Accession number :
25107669
Full Text :
https://doi.org/10.1016/j.drudis.2014.07.008