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Preliminary findings on the heritability of the neural correlates of response inhibition.
- Source :
-
Biological psychology [Biol Psychol] 2014 Dec; Vol. 103, pp. 19-23. Date of Electronic Publication: 2014 Aug 04. - Publication Year :
- 2014
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Abstract
- Imaging genetics examines genetic influences on brain structure and function. This preliminary study tested a fundamental assumption of that approach by estimating the heritability of the blood oxygen level dependent (BOLD) signal during antisaccades, a measure of response inhibition impaired in different psychiatric conditions. One hundred thirty-two healthy same-sex reared-together twins (90 monozygotic (MZ; 32 male) and 42 dizygotic (DZ; 24 male)) performed antisaccades in the laboratory. Of these, 96 twins (60 MZ, 28 male; 36 DZ, 22 male) subsequently underwent functional magnetic resonance imaging (fMRI) during antisaccades. Variation in antisaccade direction errors in the laboratory showed significant heritability (47%; 95% confidence interval (CI) 22-65). In fMRI, the contrast of antisaccades with prosaccades yielded BOLD signal in fronto-parietal-subcortical networks. Twin modelling provided tentative evidence of significant heritability (50%, 95% CI: 18-72) of BOLD in the left thalamus only. However, due to the limited power to detect heritability in this study, replications in larger samples are needed.<br /> (Copyright © 2014 Elsevier B.V. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1873-6246
- Volume :
- 103
- Database :
- MEDLINE
- Journal :
- Biological psychology
- Publication Type :
- Academic Journal
- Accession number :
- 25101865
- Full Text :
- https://doi.org/10.1016/j.biopsycho.2014.07.017