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Fetal syringomyelia.
- Source :
-
Acta neuropathologica communications [Acta Neuropathol Commun] 2014 Aug 06; Vol. 2, pp. 91. Date of Electronic Publication: 2014 Aug 06. - Publication Year :
- 2014
-
Abstract
- We explored the prevalence of syringomyelia in a series of 113 cases of fetal dysraphism and hindbrain crowding, of gestational age ranging from 17.5 to 34 weeks with the vast majority less than 26 weeks gestational age. We found syringomyelia in 13 cases of Chiari II malformations, 5 cases of Omphalocele/Exostrophy/Imperforate anus/Spinal abnormality (OEIS), 2 cases of Meckel Gruber syndrome and in a single pair of pyopagus conjoined twins. Secondary injury was not uncommon, with vernicomyelia in Chiari malformations, infarct like histology, or old hemorrhage in 8 cases of syringomyelia. Vernicomyelia did not occur in the absence of syrinx formation. The syringes extended from the sites of dysraphism, in ascending or descending patterns. The syringes were usually in a major proportion anatomically distinct from a dilated or denuded central canal and tended to be dorsal and paramedian or median. We suggest that fetal syringomyelia in Chiari II malformation and other dysraphic states is often established prior to midgestation, has contributions from the primary malformation as well as from secondary in utero injury and is anatomically and pathophysiologically distinct from post natal syringomyelia secondary to hindbrain crowding.
- Subjects :
- Anus, Imperforate embryology
Anus, Imperforate epidemiology
Arnold-Chiari Malformation embryology
Arnold-Chiari Malformation epidemiology
Ciliary Motility Disorders embryology
Ciliary Motility Disorders epidemiology
Encephalocele embryology
Encephalocele epidemiology
Fetus
Gestational Age
Hernia, Umbilical embryology
Hernia, Umbilical epidemiology
Humans
Polycystic Kidney Diseases embryology
Polycystic Kidney Diseases epidemiology
Retinitis Pigmentosa
Scoliosis embryology
Scoliosis epidemiology
Urogenital Abnormalities embryology
Urogenital Abnormalities epidemiology
Syringomyelia embryology
Syringomyelia epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 2051-5960
- Volume :
- 2
- Database :
- MEDLINE
- Journal :
- Acta neuropathologica communications
- Publication Type :
- Academic Journal
- Accession number :
- 25092126
- Full Text :
- https://doi.org/10.1186/s40478-014-0091-0