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Total synthesis of (R,R,R)-α-tocopherol through asymmetric Cu-catalyzed 1,4-addition.
- Source :
-
Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2014 Sep 15; Vol. 20 (38), pp. 12051-5. Date of Electronic Publication: 2014 Aug 01. - Publication Year :
- 2014
-
Abstract
- By introducing a disposable activating substituent at C-3, the asymmetric 1,4-addition to a notoriously unreactive 2-substituted chromenone was achieved with high levels of (2R)-stereoselectivity in the presence of a chiral Cu(I)-phosphoramidite complex as a catalyst. This paved the way for an efficient and conceptually novel synthesis of (R,R,R)-α-tocopherol from readily available starting materials.<br /> (© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
Details
- Language :
- English
- ISSN :
- 1521-3765
- Volume :
- 20
- Issue :
- 38
- Database :
- MEDLINE
- Journal :
- Chemistry (Weinheim an der Bergstrasse, Germany)
- Publication Type :
- Academic Journal
- Accession number :
- 25088810
- Full Text :
- https://doi.org/10.1002/chem.201404379