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No adjuvant effect of Bacillus thuringiensis-maize on allergic responses in mice.
- Source :
-
PloS one [PLoS One] 2014 Aug 01; Vol. 9 (8), pp. e103979. Date of Electronic Publication: 2014 Aug 01 (Print Publication: 2014). - Publication Year :
- 2014
-
Abstract
- Genetically modified (GM) foods are evaluated carefully for their ability to induce allergic disease. However, few studies have tested the capacity of a GM food to act as an adjuvant, i.e. influencing allergic responses to other unrelated allergens at acute onset and in individuals with pre-existing allergy. We sought to evaluate the effect of short-term feeding of GM Bacillus thuringiensis (Bt)-maize (MON810) on the initiation and relapse of allergic asthma in mice. BALB/c mice were provided a diet containing 33% GM or non-GM maize for up to 34 days either before ovalbumin (OVA)-induced experimental allergic asthma or disease relapse in mice with pre-existing allergy. We observed that GM-maize feeding did not affect OVA-induced eosinophilic airway and lung inflammation, mucus hypersecretion or OVA-specific antibody production at initiation or relapse of allergic asthma. There was no adjuvant effect upon GM-maize consumption on the onset or severity of allergic responses in a mouse model of allergic asthma.
- Subjects :
- Animals
Antibody Formation drug effects
Antibody Formation immunology
Asthma blood
Asthma complications
Asthma immunology
Female
Hypersensitivity blood
Hypersensitivity complications
Lung drug effects
Lung immunology
Lung pathology
Mice, Inbred BALB C
Mucus metabolism
Ovalbumin immunology
Plants, Genetically Modified
Pneumonia blood
Pneumonia complications
Pneumonia pathology
Recurrence
Adjuvants, Immunologic pharmacology
Bacillus thuringiensis physiology
Hypersensitivity immunology
Zea mays genetics
Zea mays immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1932-6203
- Volume :
- 9
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- PloS one
- Publication Type :
- Academic Journal
- Accession number :
- 25084284
- Full Text :
- https://doi.org/10.1371/journal.pone.0103979