Atom-economical access to highly substituted indenes and furan-2-ones via tandem reaction of diazo compounds and propargyl alcohols.

Authors :: Muthusamy S
Sivaguru M
Source :: Organic letters [Org Lett] 2014 Aug 15; Vol. 16 (16), pp. 4248-51. Date of Electronic Publication: 2014 Aug 01.
Publication Year :: 2014
Abstract: A facile synthesis of highly substituted as well as conjugated indene/furanone systems via a BF3·OEt2 catalyzed tandem reaction of α-diazo-esters/-amides and propargyl alcohols has been demonstrated under mild conditions. This method offers great potential for the synthesis of biologically active indene and furanone derivatives and their related polycyclic compounds.

Subjects :: Catalysis
Cyclization
Furans chemistry
Indenes chemistry
Molecular Structure
Polycyclic Compounds chemistry
Alkynes chemistry
Azo Compounds chemistry
Furans chemical synthesis
Indenes chemical synthesis
Polycyclic Compounds chemical synthesis
Propanols chemistry

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