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Is fibromuscular dysplasia underdiagnosed? A comparison of the prevalence of FMD seen in CORAL trial participants versus a single institution population of renal donor candidates.
- Source :
-
Vascular medicine (London, England) [Vasc Med] 2014 Oct; Vol. 19 (5), pp. 363-7. Date of Electronic Publication: 2014 Jul 31. - Publication Year :
- 2014
-
Abstract
- Renal artery fibromuscular dysplasia (FMD) may be underdiagnosed. We evaluated the prevalence of FMD in CORAL (Cardiovascular Outcomes in Renal Atherosclerotic Lesions) renal artery stent trial participants, in which FMD was an exclusion criterion for inclusion. We also evaluated the prevalence of FMD in a relatively healthy population of patients undergoing computed tomographic angiographic (CTA) screening for renal donor evaluation. All renal donor CTAs performed at our institution from January 2003 through November 2011 were retrospectively reviewed for the presence of FMD along with patient sex and age. These results were compared to angiographic core lab (ACL) findings for the CORAL trial. The CORAL ACL database contained 997 patients (mean age 69.3 years; 50% female). Fifty-eight (5.8%) CORAL trial patients (mean age 71.8 years; 75.9% female) demonstrated incidental FMD. The renal donor cohort included 220 patients (mean age 40.5 years; 64.5% female). Five (2.3%) demonstrated FMD (mean age 48.6 years; all female). The odds of FMD in the CORAL cohort were 2.65 times that seen in the renal donor cohort (95% CI: 1.12, 7.57). In C: onclusion, the 5.8% prevalence of renal artery FMD in the CORAL trial population, the presence of which was biased against, suggests underdiagnosis.<br /> (© The Author(s) 2014.)
- Subjects :
- Adult
Age Distribution
Aged
Angiography methods
Female
Follow-Up Studies
Humans
Kidney Transplantation methods
Male
Middle Aged
Prevalence
Renal Artery diagnostic imaging
Renal Artery pathology
Renal Artery Obstruction diagnostic imaging
Renal Artery Obstruction surgery
Risk Assessment
Severity of Illness Index
Sex Distribution
Stents
Tissue Donors
Treatment Outcome
Ultrasonography, Doppler, Duplex methods
Donor Selection
Fibromuscular Dysplasia diagnosis
Fibromuscular Dysplasia epidemiology
Renal Artery Obstruction epidemiology
Tissue and Organ Procurement
Subjects
Details
- Language :
- English
- ISSN :
- 1477-0377
- Volume :
- 19
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Vascular medicine (London, England)
- Publication Type :
- Academic Journal
- Accession number :
- 25082538
- Full Text :
- https://doi.org/10.1177/1358863X14544715