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Vascular toxicity of phosphate in chronic kidney disease: beyond vascular calcification .
- Source :
-
Circulation journal : official journal of the Japanese Circulation Society [Circ J] 2014; Vol. 78 (10), pp. 2339-46. Date of Electronic Publication: 2014 Jul 31. - Publication Year :
- 2014
-
Abstract
- Chronic kidney disease (CKD) is characterized by high cardiovascular morbidity/mortality, which is linked in part to vascular calcification (VC) and endothelial dysfunction (ED). Hyperphosphatemia, a feature of CKD, is a well-known inducer of VC in preclinical models and is associated with poor outcomes in epidemiological studies. However, it remains to be seen whether lowering phosphate levels in CKD patients reduces VC and the morbidity/mortality rate. Furthermore, it is now clear from preclinical and clinical studies that phosphate is involved in ED. The present article reviews the direct and indirect mechanisms (eg, via fibroblast growth factor 23 and/or parathyroid hormone) by which hyperphosphatemia influence the onset of VC and ED in CKD.
- Subjects :
- Animals
Endothelium, Vascular metabolism
Humans
Hyperphosphatemia blood
Hyperphosphatemia etiology
Hyperphosphatemia mortality
Hyperphosphatemia therapy
Phosphates blood
Renal Insufficiency, Chronic blood
Renal Insufficiency, Chronic complications
Renal Insufficiency, Chronic mortality
Renal Insufficiency, Chronic therapy
Vascular Calcification blood
Vascular Calcification etiology
Vascular Calcification mortality
Vascular Calcification therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1347-4820
- Volume :
- 78
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Circulation journal : official journal of the Japanese Circulation Society
- Publication Type :
- Academic Journal
- Accession number :
- 25077548
- Full Text :
- https://doi.org/10.1253/circj.cj-14-0735