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Allergy-related evidences in relation to serum IgE: data from the China state key laboratory of respiratory disease, 2008-2013.
- Source :
-
Biomedical and environmental sciences : BES [Biomed Environ Sci] 2014 Jul; Vol. 27 (7), pp. 495-505. - Publication Year :
- 2014
-
Abstract
- Objective: To investigate the serum total IgE (tIgE) and specific IgE (sIgE) to common allergens among allergic patients in Guangzhou, China.<br />Methods: 7 085 patients were examined for tIgE and sIgE to 15 allergens, based on the protocols of reversed enzyme allergosorbent test and the sandwich enzyme-linked immunosorbent assay.<br />Results: 3 758 (53.04%) patients tested positive for tIgE, and 4 640 (65.49%) for sIgE. Der pteronyssinus, Der farinae, eggs, and cow's milk were the most common allergens leading to higher positive rates of sIgE responses. Several peaks of sensitization were: Der pteronyssinus, Der farinae, and Blomia tropicalis at age 10-12; cow's milk at age below 3; eggs at age 4-6. The mean level and positive rate of tIgE tended to increase in subjects sensitized to more allergens. Sensitization to Der pteronyssinus (OR, 1.6; P<0.05), Der farinae (OR, 1.5; P<0.05), Blomia tropicalis (OR, 1.4; P<0.05), Blattella germanica (OR, 1.5; P<0.05), cow's milk (OR, 1.3; P<0.05), and soy beans (OR, 2.0; P<0.05) were independently correlated with allergy-related conditions in preliminary diagnosis.<br />Conclusion: The major allergens in Guangzhou include Der pteronyssinus, Der farinae, cow's milk, and eggs. Sensitization to these allergens appears to be predictors of allergy-related disorder.<br /> (Copyright © 2014 The Editorial Board of Biomedical and Environmental Sciences. Published by China CDC. All rights reserved.)
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Allergens immunology
Child
Child, Preschool
China epidemiology
Female
Humans
Hypersensitivity epidemiology
Hypersensitivity immunology
Infant
Laboratories
Male
Middle Aged
Odds Ratio
Respiratory Tract Diseases epidemiology
Retrospective Studies
Young Adult
Hypersensitivity blood
Immunoglobulin E blood
Respiratory Tract Diseases blood
Respiratory Tract Diseases immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0895-3988
- Volume :
- 27
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Biomedical and environmental sciences : BES
- Publication Type :
- Academic Journal
- Accession number :
- 25073908
- Full Text :
- https://doi.org/10.3967/bes2014.081