Back to Search
Start Over
Heparanase procoagulant activity is elevated and predicts survival in non-small cell lung cancer patients.
- Source :
-
Thrombosis research [Thromb Res] 2014 Sep; Vol. 134 (3), pp. 639-42. Date of Electronic Publication: 2014 Jul 12. - Publication Year :
- 2014
-
Abstract
- Background: Heparanase is implicated in angiogenesis and tumor progression. We had earlier demonstrated that heparanase may also affect the hemostatic system in a non-enzymatic manner. It forms a complex and enhances the activity of the blood coagulation initiator- tissue factor (TF). Although increased heparanase antigen level in the plasma and biopsies of cancer patients was previously demonstrated, in the present study we evaluated, for the first time, the heparanase procoagulant activity in the plasma of patients with lung cancer.<br />Materials and Methods: Sixty five patients with non-small cell lung cancer at presentation and twenty controls were recruited. Plasma was studied for TF / heparanase procoagulant activity, TF activity and heparanase procoagulant activity using chromogenic assay and heparanase antigen levels by ELISA.<br />Results: Heparanase antigen levels were higher in the study group compared to control (P=0.05). TF / heparanase activity, and even more apparent, heparanase procoagulant activity were significantly higher in the study group compared to controls (P=0.008, P<0.0001, respectively). No significant difference was observed in the TF activity between the groups. Survival of patients with heparanase procoagulant activity higher than 31 ng/ml predicted a mean survival of 9 ± 1.3 months while heparanase procoagulant activity of 31 ng/ml or lower predicted a mean survival of 24 ± 4 months (P=0.001). Heparanase procoagulant activity was higher than 31 ng/ml in the four cases of thrombosis detected during the follow-up period.<br />Conclusions: Elevated heparanase procoagulant activity in patients with lung cancer reveals a new mechanism of coagulation system activation in malignancy. Heparanase procoagulant activity can potentially be used as a predictor for survival.<br /> (Copyright © 2014 Elsevier Ltd. All rights reserved.)
- Subjects :
- Aged
Carcinoma, Non-Small-Cell Lung blood
Carcinoma, Non-Small-Cell Lung complications
Carcinoma, Non-Small-Cell Lung mortality
Case-Control Studies
Female
Humans
Kaplan-Meier Estimate
Lung Neoplasms blood
Lung Neoplasms complications
Lung Neoplasms mortality
Male
Middle Aged
Prognosis
Risk Factors
Thrombosis blood
Thrombosis enzymology
Thrombosis etiology
Time Factors
Up-Regulation
Biomarkers, Tumor blood
Blood Coagulation
Carcinoma, Non-Small-Cell Lung enzymology
Glucuronidase blood
Lung Neoplasms enzymology
Subjects
Details
- Language :
- English
- ISSN :
- 1879-2472
- Volume :
- 134
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Thrombosis research
- Publication Type :
- Academic Journal
- Accession number :
- 25065557
- Full Text :
- https://doi.org/10.1016/j.thromres.2014.07.006