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Genome-wide screening for DNA variants associated with reading and language traits.
- Source :
-
Genes, brain, and behavior [Genes Brain Behav] 2014 Sep; Vol. 13 (7), pp. 686-701. Date of Electronic Publication: 2014 Aug 29. - Publication Year :
- 2014
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Abstract
- Reading and language abilities are heritable traits that are likely to share some genetic influences with each other. To identify pleiotropic genetic variants affecting these traits, we first performed a genome-wide association scan (GWAS) meta-analysis using three richly characterized datasets comprising individuals with histories of reading or language problems, and their siblings. GWAS was performed in a total of 1862 participants using the first principal component computed from several quantitative measures of reading- and language-related abilities, both before and after adjustment for performance IQ. We identified novel suggestive associations at the SNPs rs59197085 and rs5995177 (uncorrected Pāāā10(-7) for each SNP), located respectively at the CCDC136/FLNC and RBFOX2 genes. Each of these SNPs then showed evidence for effects across multiple reading and language traits in univariate association testing against the individual traits. FLNC encodes a structural protein involved in cytoskeleton remodelling, while RBFOX2 is an important regulator of alternative splicing in neurons. The CCDC136/FLNC locus showed association with a comparable reading/language measure in an independent sample of 6434 participants from the general population, although involving distinct alleles of the associated SNP. Our datasets will form an important part of on-going international efforts to identify genes contributing to reading and language skills.<br /> (© 2014 The Authors. Genes, Brain and Behavior published by International Behavioural and Neural Genetics Society and John Wiley & Sons Ltd.)
Details
- Language :
- English
- ISSN :
- 1601-183X
- Volume :
- 13
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Genes, brain, and behavior
- Publication Type :
- Academic Journal
- Accession number :
- 25065397
- Full Text :
- https://doi.org/10.1111/gbb.12158