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Elevated remnant cholesterol in 25-hydroxyvitamin D deficiency in the general population: Mendelian randomization study.
- Source :
-
Circulation. Cardiovascular genetics [Circ Cardiovasc Genet] 2014 Oct; Vol. 7 (5), pp. 650-8. Date of Electronic Publication: 2014 Jul 27. - Publication Year :
- 2014
-
Abstract
- Background: Low plasma 25-hydroxyvitamin D [25(OH)D] levels are associated with high cardiovascular risk. This may be because that low 25(OH)D levels are associated with high levels of atherogenic lipoproteins, but whether these 2 risk factors are genetically associated is unknown. We tested this hypothesis.<br />Methods and Results: Using a Mendelian randomization approach, potential genetic associations between plasma levels of atherogenic lipoproteins and 25(OH)D were examined in ≤85,868 white, Danish individuals in whom we genotyped for variants affecting plasma levels of 25(OH)D, nonfasting remnant cholesterol, low-density lipoprotein-cholesterol, and high-density lipoprotein-cholesterol. Lipoprotein levels were measured in all and 25(OH)D levels in 31,435. A doubling in nonfasting remnant cholesterol levels was observationally and genetically associated with -6.0%(95% confidence interval [CI], -6.5% to -5.5%) and -8.9% (95% CI, -15% to -2.3%) lower plasma 25(OH)D levels. For low-density lipoprotein-cholesterol levels, corresponding values were -4.6% (95% CI, -5.4% to -3.7%) observationally and -11% (95% CI, -29% to +6.9%) genetically. In contrast, a halving in high-density lipoprotein-cholesterol levels was observationally associated with -1.5% (95% CI, -2.2% to -0.7%) lower but genetically associated with +20% (95% CI, +7.4% to +34%) higher plasma 25(OH)D levels. Plasma levels of lipoprotein(a) and 25(OH)D did not associate. Finally, low 25(OH)D levels did not associate genetically with levels of remnant and low-density lipoprotein-cholesterol.<br />Conclusions: Genetically elevated nonfasting remnant cholesterol is associated with low 25(OH)D levels, whereas genetically reduced high-density lipoprotein-cholesterol is not associated with low 25(OH)D levels. These findings suggest that low 25(OH)D levels observationally is simply a marker for elevated atherogenic lipoproteins and question a role for vitamin D supplementation in the prevention of cardiovascular disease.<br /> (© 2014 American Heart Association, Inc.)
- Subjects :
- Aged
Atherosclerosis blood
Cholesterol, HDL blood
Cholesterol, LDL blood
Data Interpretation, Statistical
Denmark
Female
Genetic Predisposition to Disease
Genotype
Humans
Male
Middle Aged
Random Allocation
Risk Factors
Vitamin D blood
Cardiovascular Diseases blood
Cardiovascular Diseases genetics
Cholesterol blood
Hypercholesterolemia genetics
Vitamin D analogs & derivatives
Vitamin D Deficiency genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1942-3268
- Volume :
- 7
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Circulation. Cardiovascular genetics
- Publication Type :
- Academic Journal
- Accession number :
- 25065375
- Full Text :
- https://doi.org/10.1161/CIRCGENETICS.113.000416