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Transcriptomic response to Yersinia pestis: RIG-I like receptor signaling response is detrimental to the host against plague.
- Source :
-
Journal of genetics and genomics = Yi chuan xue bao [J Genet Genomics] 2014 Jul 20; Vol. 41 (7), pp. 379-96. Date of Electronic Publication: 2014 Jun 03. - Publication Year :
- 2014
-
Abstract
- Bacterial pathogens have evolved various mechanisms to modulate host immune responses for successful infection. In this study, RNA-sequencing technology was used to analyze the responses of human monocytes THP1 to Yersinia pestis infection. Over 6000 genes were differentially expressed over the 12 h infection. Kinetic responses of pathogen recognition receptor signaling pathways, apoptosis, antigen processing, and presentation pathway and coagulation system were analyzed in detail. Among them, RIG-I-like receptor (RLR) signaling pathway, which was established for antiviral defense, was significantly affected. Mice lacking MAVS, the adaptor of the RLR signaling pathway, were less sensitive to infection and exhibited lower IFN-β production, higher Th1-type cytokines IFN-γ and IL-12 production, and lower Th2-type cytokines IL-4 and IL-13 production in the serum compared with wild-type mice. Moreover, infection of pathogenic bacteria other than Y. pestis also altered the expression of the RLR pathway, suggesting that the response of RLR pathway to bacterial infection is a universal mechanism.<br /> (Copyright © 2014 The Society of Chinese Scholars on Exercise Physiology and Fitness. Published by Elsevier Ltd. All rights reserved.)
- Subjects :
- Adaptor Proteins, Signal Transducing deficiency
Animals
Antigen Presentation
Antigens, Bacterial immunology
Apoptosis
Blood Coagulation
Cell Line
Cytokines metabolism
DEAD Box Protein 58
DEAD-box RNA Helicases genetics
Humans
Immunity, Innate
Mice
Mice, Inbred C57BL
Plague immunology
Plague physiopathology
Receptors, Immunologic
Yersinia pestis immunology
DEAD-box RNA Helicases metabolism
Gene Expression Profiling
Host-Pathogen Interactions
Plague genetics
Plague pathology
Signal Transduction
Yersinia pestis physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1673-8527
- Volume :
- 41
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Journal of genetics and genomics = Yi chuan xue bao
- Publication Type :
- Academic Journal
- Accession number :
- 25064677
- Full Text :
- https://doi.org/10.1016/j.jgg.2014.05.006