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Increased expression of GAP43 in interneurons in a rat model of experimental polymicrogyria.
- Source :
-
Journal of child neurology [J Child Neurol] 2015 May; Vol. 30 (6), pp. 716-28. Date of Electronic Publication: 2014 Jul 23. - Publication Year :
- 2015
-
Abstract
- To investigate seizure susceptibility in polymicrogyria, the seizure threshold and growth-associated protein GAP43 expression were analyzed in a rat experimental model of polymicrogyria induced by intracerebral injection of ibotenate. A total of 72 neonates from 9 pregnant rats were used. Intraperitoneal pentylenetetrazole injection did not induce any seizure activity in the control rats, although it elicited seizures of variable severity in the polymicrogyria rats. Fluoro-Jade B-positive degenerating interneurons were found in the polymicrogyria brains; however, no such neurons were detected in the control brains. In the polymicrogyria rats, the GAP43 expression was significantly and widely distributed in the brain, and the percentage of parvalbumin-positive interneurons in the GAP43-positive cells was significantly higher than that observed in the nonphosphorylated neurofilament-positive pyramidal cells. We conclude that the relatively selective vulnerability of inhibitory interneurons constitutes the basis for the decreased seizure threshold observed in this model of polymicrogyria.<br /> (© The Author(s) 2014.)
- Subjects :
- Animals
Animals, Newborn
Brain drug effects
Disease Models, Animal
Female
Ibotenic Acid toxicity
Interneurons drug effects
Male
Parvalbumins metabolism
Pentylenetetrazole toxicity
Polymicrogyria chemically induced
Polymicrogyria physiopathology
Pregnancy
Pyramidal Cells drug effects
Pyramidal Cells metabolism
Rats
Seizures chemically induced
Brain metabolism
GAP-43 Protein metabolism
Interneurons metabolism
Polymicrogyria metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1708-8283
- Volume :
- 30
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of child neurology
- Publication Type :
- Academic Journal
- Accession number :
- 25061039
- Full Text :
- https://doi.org/10.1177/0883073814541476