Novel type of VanB2 teicoplanin-resistant hospital-associated Enterococcus faecium.

Authors :: Santona A
Paglietti B
Al-Qahtani AA
Bohol MF
Senok A
Deligios M
Rubino S
Al-Ahdal MN
Source :: International journal of antimicrobial agents [Int J Antimicrob Agents] 2014 Aug; Vol. 44 (2), pp. 156-9. Date of Electronic Publication: 2014 Jun 17.
Publication Year :: 2014
Abstract: Seven high-risk clones of vancomycin-resistant Enterococcus faecium (VREF) belonging to clonal complex 17 were identified using multilocus sequence typing (MLST) among clinical isolates from Saudi Arabia. Among these isolates, a new hospital-associated sequence type (ST795), VanB(2)-type teicoplanin-resistant strain was detected. Its unusual phenotype resulted from a new combination of mutations in the ddl, vanS and vanW genes, which confirmed the trend of evolution in VanB-type resistance. Furthermore, characteristics of adaptation and persistence in the hospital environment of ST795 were emphasised by the presence of genes and clusters recognised to be specific for hospital-associated VREF.<br /> (Copyright © 2014 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.)

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