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Association of severe thrombocytopenia and poor prognosis in pregnancies with aplastic anemia.
- Source :
-
PloS one [PLoS One] 2014 Jul 24; Vol. 9 (7), pp. e103066. Date of Electronic Publication: 2014 Jul 24 (Print Publication: 2014). - Publication Year :
- 2014
-
Abstract
- Purpose: We sought to estimate the risks of adverse obstetric outcomes and disease outcomes associated with severe thrombocytopenia in pregnant women with aplastic anemia (AA).<br />Methods: In a retrospective study, we compared demographics, clinical characteristics, laboratory results, and outcomes between severe thrombocytopenia (ST) and non-severe thrombocytopenia (non-ST) groups comprising pregnant women with AA.<br />Results: Of 61 AA patients, 43 (70%) were diagnosed as AA before pregnancy and 18 (30%) were AA during pregnancy. The ST group exhibited lower gestational age at nadir of platelet count (26.0 versus 37.0 weeks, p<0.001) and at delivery (37.3 versus 39.1 weeks, p = 0.008), and a higher rate of bleeding gums (33.8 versus 7.7%, p = 0.015) than the non-ST group. In addition, the ST group exhibited more transfusions during pregnancy (72.7 versus 15.4%, p<0.001) and postpartum period (45.0 versus 2.7%, p<0.001), and more bone marrow transplant after delivery (25.0 versus 0.0%, p<0.001) than the non-ST group. The ST group had a higher odds ratio of composite disease complications (OR, 9.63; 95% CI, 2.82-32.9; p<0.001) and composite obstetric complications (OR, 6.78; 95% CI, 2.11-21.8; p = 0.001) than the non-ST group.<br />Conclusions: Severe thrombocytopenia is more associated with obstetric and disease complications than is non-severe thrombocytopenia in pregnant women with AA.
- Subjects :
- Adult
Anemia, Aplastic complications
Anemia, Aplastic pathology
Anemia, Aplastic therapy
Bone Marrow Transplantation
Cesarean Section statistics & numerical data
Delivery, Obstetric statistics & numerical data
Female
Gestational Age
Humans
Odds Ratio
Platelet Count
Platelet Transfusion
Pregnancy
Pregnancy Complications, Hematologic pathology
Pregnancy Complications, Hematologic prevention & control
Prognosis
Retrospective Studies
Severity of Illness Index
Thrombocytopenia complications
Thrombocytopenia pathology
Thrombocytopenia therapy
Anemia, Aplastic diagnosis
Pregnancy Complications, Hematologic diagnosis
Thrombocytopenia diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 1932-6203
- Volume :
- 9
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- PloS one
- Publication Type :
- Academic Journal
- Accession number :
- 25058151
- Full Text :
- https://doi.org/10.1371/journal.pone.0103066