Hepatitis B virus antibody levels 7 to 9 years after booster vaccination in Alaska native persons.

Authors :: Keck JW
Bulkow LR
Raczniak GA
Negus SE
Zanis CL
Bruce MG
Spradling PR
Teshale EH
McMahon BJ
Source :: Clinical and vaccine immunology : CVI [Clin Vaccine Immunol] 2014 Sep; Vol. 21 (9), pp. 1339-42. Date of Electronic Publication: 2014 Jul 23.
Publication Year :: 2014
Abstract: Hepatitis B antibody persistence was assessed in individuals who had previously received a vaccine booster. We measured hepatitis B surface antigen antibody (anti-HBs) levels 7 to 9 years post-hepatitis B booster in individuals with primary vaccination at birth. While 95 (91.3%) of 104 participants had detectable anti-HBs (minimum, 0.1 mIU/ml; maximum, 1,029 mIU/ml), only 43 (41%) had protective levels of ≥10 mIU/ml. Pre- and week 4 postbooster anti-HBs levels were significant predictors of hepatitis B immunity at follow-up (P < 0.001). Almost all participants had detectable anti-HBs 7 to 9 years after the hepatitis B vaccine booster, but less than half had levels ≥10 mIU/ml.<br /> (Copyright © 2014, American Society for Microbiology. All Rights Reserved.)

Subjects :: Adolescent
Adult
Alaska
Child
Child, Preschool
Female
Hepatitis B immunology
Hepatitis B Vaccines administration & dosage
Humans
Infant
Infant, Newborn
Male
Population Groups
Time Factors
Hepatitis B prevention & control
Hepatitis B Antibodies blood
Hepatitis B Vaccines immunology
Hepatitis B virus immunology
Immunization, Secondary

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