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[Prophylaxis of blood loss and allogenic blood transfusion with fibrinolysis inhibitors produced in Russian Federation in patients undergoing cardiac surgery].
- Source :
-
Anesteziologiia i reanimatologiia [Anesteziol Reanimatol] 2014 Mar-Apr (2), pp. 59-64. - Publication Year :
- 2014
-
Abstract
- Significant bleeding during cardiac surgery, enough to cause re-exploration and/or blood transfusion, increases morbidity and mortality. Bleeding after cardiopulmonary bypass is related to multiple factors: endothelial dysfunction, thrombocytopenia, dilution coagulopathy. Hyperfibrinolysis is one of the important contributors to increased bleeding. To compare the effect of aprotinin with the effect of lysine analogues (aminomethylbenzoic acid and epsilon aminocaproic acid) examined 63 patients were divided into three equal groups depending on the product used for the prevention of activation of fibrinolysis. Data from rotational thromboelastometry measurements (Rotem Gamma Pentapharm, Germany), blood loss and transfusion were collected. The results confirm that used in the study antifibrinolytics: the lysine analogues aminomethylbenzoic acid and epsilon aminocaproic acid prevent hyperfibrinolysis after cardiopulmonary bypass as well as aprotinin.
- Subjects :
- Adult
Aged
Aminocaproic Acid therapeutic use
Aprotinin therapeutic use
Cardiopulmonary Bypass methods
Female
Humans
Male
Middle Aged
Russia
Thrombelastography methods
Transplantation, Homologous
Treatment Outcome
Young Adult
para-Aminobenzoates therapeutic use
Antifibrinolytic Agents therapeutic use
Blood Loss, Surgical prevention & control
Blood Transfusion methods
Cardiac Surgical Procedures methods
Subjects
Details
- Language :
- Russian
- ISSN :
- 0201-7563
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Anesteziologiia i reanimatologiia
- Publication Type :
- Academic Journal
- Accession number :
- 25055497