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Association of cardiometabolic risk profile with prehypertension accompany hyperhomocysteinaemia.
- Source :
-
Clinical and experimental hypertension (New York, N.Y. : 1993) [Clin Exp Hypertens] 2015; Vol. 37 (3), pp. 218-22. Date of Electronic Publication: 2014 Jul 22. - Publication Year :
- 2015
-
Abstract
- Background: Study suggested that elevated homocysteine showed a multiplicative effect on cardiovascular diseases in hypertensive subjects. It was reported that elevated homocysteine level was independently associated with increased arterial stiffness in prehypertensives. It remains unclear whether prehypertensives combined with elevated homocysteine have adverse cardiovascular risk factors. We aimed to compare cardiometabolic risk profile between prehypertensives with hyperhomocysteinaemia and those without either condition.<br />Methods: Plasma total homocysteine and risk profile were determined among 874 Chinese non-hypertension individuals in Tianjin. They were subdivided into four groups: prehypertension with hyperhomocysteinaemia (≥10 μmol/L), prehypertension with normal homocysteine (<10 μmol/L), normotension with hyperhomocysteinaemia, normotension with normol homocysteine, respectively.<br />Results: In 874 participants, 22.5% of them were male, mean age was 56.8 years. In multiple comparisons, after adjustment for age, gender, smoking, alcohol, exercise, education prehypertensives had higher body mass index (BMI) and high sensitive C reactive protein (hs-CRP) than normotensives (p < 0.05, respectively); Only prehypertensive subjects with hyperhomocysteinaemia had higher triglyceride and serum uric acid compared to normotensive subjects, and lower HDL cholesterol than normotensives with normal homocysteine (p < 0.05, respectively). However, the significance of higher hs-CRP, uric acid and lower HDL cholesterol were abolished when further adjustment was made for BMI.<br />Conclusion: The combination of prehypertension and hyperhomocusteinaemia increases the likelihood of having adverse cardiometabolic risk profile. Strict lipid management and weigh control may be needed in prehypertensives with elevated homocysteine.
- Subjects :
- Blood Pressure
Body Mass Index
C-Reactive Protein analysis
China epidemiology
Dyslipidemias complications
Dyslipidemias metabolism
Female
Humans
Male
Middle Aged
Population Surveillance
Risk Factors
Cardiovascular Diseases epidemiology
Cardiovascular Diseases metabolism
Cardiovascular Diseases prevention & control
Hyperhomocysteinemia complications
Hyperhomocysteinemia diagnosis
Hyperhomocysteinemia metabolism
Prehypertension diagnosis
Prehypertension etiology
Prehypertension metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1525-6006
- Volume :
- 37
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Clinical and experimental hypertension (New York, N.Y. : 1993)
- Publication Type :
- Academic Journal
- Accession number :
- 25051302
- Full Text :
- https://doi.org/10.3109/10641963.2014.939276