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Ratio of hepatic arterial flow to recipient body weight predicts biliary complications after deceased donor liver transplantation.
- Source :
-
HPB : the official journal of the International Hepato Pancreato Biliary Association [HPB (Oxford)] 2014 Dec; Vol. 16 (12), pp. 1083-7. Date of Electronic Publication: 2014 Jul 18. - Publication Year :
- 2014
-
Abstract
- Objectives: Adequate hepatic arterial (HA) flow to the bile duct is essential in liver transplantation. This study was conducted to determine if the ratio of directly measured HA flow to weight is related to the occurrence of biliary complications after deceased donor liver transplantation.<br />Methods: A retrospective review of 2684 liver transplants carried out over a 25-year period was performed using data sourced from a prospectively maintained database. Rates of biliary complications (biliary leaks, anastomotic and non-anastomotic strictures) were compared between two groups of patients with HA flow by body weight of, respectively, <5 ml/min/kg (n = 884) and ≥5 ml/min/kg (n = 1800).<br />Results: Patients with a lower ratio of HA flow to weight had higher body weight (92 kg versus 76 kg; P < 0.001) and lower HA flow (350 ml/min versus 550 ml/min; P < 0.001). A lower ratio of HA flow to weight was associated with higher rates of biliary complications at 2 months, 6 months and 12 months (19.8%, 28.2% and 31.9% versus 14.8%, 22.4% and 25.8%, respectively; P < 0.001).<br />Conclusions: A ratio of HA flow to weight of < 5 ml/min/kg is associated with higher rates of biliary complications. This ratio may be a useful parameter for application in the prevention and early detection of biliary complications.<br /> (© 2014 International Hepato-Pancreato-Biliary Association.)
- Subjects :
- Adult
Blood Flow Velocity
Cholestasis etiology
Female
Hepatic Artery physiopathology
Humans
Male
Middle Aged
Regional Blood Flow
Retrospective Studies
Risk Assessment
Risk Factors
Texas
Treatment Outcome
Young Adult
Anastomotic Leak etiology
Biliary Tract Diseases etiology
Body Weight
Hepatic Artery surgery
Liver Transplantation adverse effects
Liver Transplantation methods
Transplant Recipients
Subjects
Details
- Language :
- English
- ISSN :
- 1477-2574
- Volume :
- 16
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- HPB : the official journal of the International Hepato Pancreato Biliary Association
- Publication Type :
- Academic Journal
- Accession number :
- 25041738
- Full Text :
- https://doi.org/10.1111/hpb.12318