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Inhibitory effect of (-)-epigallocatechin gallate on carcinogenesis with N-ethyl-N'-nitro-N-nitrosoguanidine in mouse duodenum.

Authors :
Fujita Y
Yamane T
Tanaka M
Kuwata K
Okuzumi J
Takahashi T
Fujiki H
Okuda T
Source :
Japanese journal of cancer research : Gann [Jpn J Cancer Res] 1989 Jun; Vol. 80 (6), pp. 503-5.
Publication Year :
1989

Abstract

(-)-Epigallocatechin gallate (EGCG) is the main polyphenolic constituent of green tea infusion and inhibits tumor promotion by teleocidin in two-stage carcinogenesis on mouse skin. In this work, EGCG was found to inhibit tumor promotion in the gastrointestinal tract in a model system of mouse duodenal carcinogenesis with N-ethyl-N'-nitro-N-nitrosoguanidine. The duodenal tumors that developed were studied stereomicroscopically and histologically.

Details

Language :
English
ISSN :
0910-5050
Volume :
80
Issue :
6
Database :
MEDLINE
Journal :
Japanese journal of cancer research : Gann
Publication Type :
Academic Journal
Accession number :
2503469
Full Text :
https://doi.org/10.1111/j.1349-7006.1989.tb01666.x