Positivity to p-ANCA in patients with status epilepticus.

Authors :: Ferlazzo E
Gambardella A
Bellavia M
Gasparini S
Mumoli L
Labate A
Cianci V
Russo C
Aguglia U
Source :: BMC neurology [BMC Neurol] 2014 Jul 17; Vol. 14, pp. 148. Date of Electronic Publication: 2014 Jul 17.
Publication Year :: 2014
Abstract: Background: Status epilepticus (SE) may occur in the setting of several internal or neurologic diseases. Anti-neutrophilic cytoplasmic antibodies (ANCA) are a group of Ig that may be observed in patients with different autoimmune disorders but are particularly associated with systemic vasculitis named ANCA-associated-vasculities (AAV). We herein report 3 patients with SE and positivity to p-ANCA.<br />Case Presentation: One patient had a catastrophic evolution and died 5 months after disease onset. The other two patients had a good outcome and remained seizure-free at 30 months and 5 years of follow-up respectively.<br />Conclusion: This report highlights the importance of considering ANCA dosage in patients with SE of unclear origin.