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Therapeutic dose of acetaminophen as a possible risk factor for acute kidney injury: learning from two healthy young adult cases.
- Source :
-
Internal medicine (Tokyo, Japan) [Intern Med] 2014; Vol. 53 (14), pp. 1531-4. Date of Electronic Publication: 2014 Jul 15. - Publication Year :
- 2014
-
Abstract
- Acetaminophen overdose can lead to severe liver and kidney failure; however, the risk of therapeutic doses in healthy individuals causing acute kidney injury (AKI) is less clear. We herein describe the cases of two young adults with renal biopsy-proven acute tubular necrosis under a therapeutic dose of acetaminophen. The first patient exhibited mild reversible renal insufficiency, whereas, in the second case, the patient demonstrated a slightly increased serum creatinine level and enlarged kidneys and the administration of contrast media and antibiotics may have worsened the renal dysfunction, leading to the need for temporal hemodialysis. Physicians should be aware of the risk of acetaminophen causing AKI and avoid administering other nephrotoxic agents in such cases.
- Subjects :
- Acetaminophen administration & dosage
Acute Kidney Injury diagnosis
Adult
Analgesics, Non-Narcotic administration & dosage
Analgesics, Non-Narcotic poisoning
Biopsy
Dose-Response Relationship, Drug
Female
Humans
Kidney pathology
Photomicrography
Risk Factors
Young Adult
Acetaminophen poisoning
Acute Kidney Injury chemically induced
Drug Overdose complications
Subjects
Details
- Language :
- English
- ISSN :
- 1349-7235
- Volume :
- 53
- Issue :
- 14
- Database :
- MEDLINE
- Journal :
- Internal medicine (Tokyo, Japan)
- Publication Type :
- Academic Journal
- Accession number :
- 25030567
- Full Text :
- https://doi.org/10.2169/internalmedicine.53.1502