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Seminal plasma protein in renal cell carcinoma: expression of semenogelin I is a predictor for cancer progression and prognosis.
- Source :
-
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine [Tumour Biol] 2014 Sep; Vol. 35 (9), pp. 9095-100. Date of Electronic Publication: 2014 Jun 11. - Publication Year :
- 2014
-
Abstract
- The incidence of renal cell carcinoma (RCC) has been steadily rising each year. There are currently few recognized biomarkers for the diagnosis and prognosis of RCC. We investigated semenogelin I (Sg I) expression and its clinical significance in patients with RCC. The expression levels of Sg I and its protein were measured by qPCR and Western blotting, respectively. Immunohistochemistry was used to investigate the protein expression of Sg I in RCC and normal renal tissue from 53 patients. The Kaplan-Meier method and log-rank test were used to evaluate the data. By qRCR (p < 0.01) and Western blot, the level of Sg I expression in benign tissues was higher than that in RCC tissues. Expression of Sg I was observed in 30 (57 %) RCC cases, which was significantly lower than that observed in benign renal tissues from the same patients [Sg I positive in 53 (100 %) cases (p < 0.0001)] by immunohistochemistry. There was an inverse relation between Sg I expression and clinical stage (pT1-2 vs pT3-4, p < 0.0001). Patients with Sg I-negative tumor had a significantly higher risk of recurrence (Kaplan-Meier and log-rank tests, p < 0.0001). There was low Sg I expression in RCC. Sg I expression has potential value in predicting cancer progression and prognosis. These findings support the use of Sg I as a novel biomarker for RCC.
- Subjects :
- Adult
Aged
Biomarkers, Tumor genetics
Biomarkers, Tumor metabolism
Blotting, Western
Carcinoma, Renal Cell metabolism
Carcinoma, Renal Cell pathology
Disease Progression
Female
Gene Expression Regulation, Neoplastic
Humans
Immunohistochemistry
Kaplan-Meier Estimate
Kidney metabolism
Kidney pathology
Kidney Neoplasms metabolism
Kidney Neoplasms pathology
Male
Middle Aged
Neoplasm Recurrence, Local
Neoplasm Staging
Predictive Value of Tests
Prognosis
Reverse Transcriptase Polymerase Chain Reaction
Seminal Plasma Proteins metabolism
Seminal Vesicle Secretory Proteins metabolism
Young Adult
Carcinoma, Renal Cell genetics
Kidney Neoplasms genetics
Seminal Plasma Proteins genetics
Seminal Vesicle Secretory Proteins genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1423-0380
- Volume :
- 35
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 25027395
- Full Text :
- https://doi.org/10.1007/s13277-014-2184-6