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The impacts of neoadjuvant chemotherapy and of debulking surgery on survival from advanced ovarian cancer.
- Source :
-
Gynecologic oncology [Gynecol Oncol] 2014 Sep; Vol. 134 (3), pp. 462-7. Date of Electronic Publication: 2014 Jul 12. - Publication Year :
- 2014
-
Abstract
- Objectives: Women with advanced ovarian cancer are treated with chemotherapy either before (neoadjuvant) or after surgery (primary debulking). The goal is to leave no residual disease post-surgery; for women treated with primary debulking surgery this has been associated with an improvement in survival. It has not been shown that the survival advantage conferred by having no residual disease post-surgery is present for women who receive neoadjuvant chemotherapy.<br />Methods: We reviewed the records of 326 women with stage IIIc or IV serous ovarian cancer. We determined if they received neoadjuvant chemotherapy or primary debulking surgery and we measured the extent of residual disease post-surgery. We estimated seven-year survival rates for women after various treatments.<br />Results: Women who had neoadjuvant chemotherapy were more likely to have no residual disease than women who had primary debulking surgery (50.1% versus 41.5%; p=0.03) but they experienced inferior seven-year survival (8.6% versus 41%; p<0.0001). Among women who had primary debulking surgery, those with no residual disease had much better seven-year survival than women who had any residual disease (73.6% versus 21.0%; p<0.0001). Women who had no residual disease after debulking surgery and who received intraperitoneal chemotherapy had a seven-year survival of 90%.<br />Conclusions: Neoadjuvant chemotherapy should be reserved for ovarian cancer patients who are not candidates for primary debulking surgery. Among women with no residual disease after primary debulking surgery, intraperitoneal chemotherapy extends survival.<br /> (Copyright © 2014 Elsevier Inc. All rights reserved.)
- Subjects :
- Adult
Aged
Chemotherapy, Adjuvant
Female
Gynecologic Surgical Procedures methods
Humans
Middle Aged
Neoadjuvant Therapy
Neoplasm Staging
Neoplasm, Residual
Ovarian Neoplasms mortality
Ovarian Neoplasms pathology
Postoperative Period
Survival Rate
Ovarian Neoplasms drug therapy
Ovarian Neoplasms surgery
Subjects
Details
- Language :
- English
- ISSN :
- 1095-6859
- Volume :
- 134
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Gynecologic oncology
- Publication Type :
- Academic Journal
- Accession number :
- 25026637
- Full Text :
- https://doi.org/10.1016/j.ygyno.2014.07.004