cCMP is a substrate for MRP5.

Authors :: Laue S
Winterhoff M
Kaever V
van den Heuvel JJ
Russel FG
Seifert R
Source :: Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2014 Sep; Vol. 387 (9), pp. 893-5. Date of Electronic Publication: 2014 Jul 15.
Publication Year :: 2014
Abstract: The cyclic pyrimidine nucleotide cCMP has been suggested to serve as second messenger. However, phosphodiesterases studied so far do not hydrolyze cCMP. Therefore, we searched for alternative cCMP inactivation mechanisms. cCMP is a substrate for multidrug resistance protein 5, indicating that export from the cytosol into the extracellular space is an important inactivation mechanism for cCMP.