Validation of an enzyme-linked immunosorbent assay that detects Histoplasma capsulatum antigenuria in Colombian patients with AIDS for diagnosis and follow-up during therapy.

Authors :: Caceres DH
Scheel CM
Tobón AM
Ahlquist Cleveland A
Restrepo A
Brandt ME
Chiller T
Gómez BL
Source :: Clinical and vaccine immunology : CVI [Clin Vaccine Immunol] 2014 Sep; Vol. 21 (9), pp. 1364-8. Date of Electronic Publication: 2014 Jul 09.
Publication Year :: 2014
Abstract: We validated an antigen capture enzyme-linked immunosorbent assay (ELISA) in Colombian persons with AIDS and proven histoplasmosis and evaluated the correlation between antigenuria and clinical improvement during follow-up. The sensitivity of the Histoplasma capsulatum ELISA was 86%, and the overall specificity was 94%. The antigen test successfully monitored the response to therapy.<br /> (Copyright © 2014, American Society for Microbiology. All Rights Reserved.)

Subjects :: AIDS-Related Opportunistic Infections diagnosis
Cohort Studies
Colombia
Enzyme-Linked Immunosorbent Assay methods
Histoplasmosis drug therapy
Humans
Prospective Studies
Sensitivity and Specificity
Antigens, Fungal urine
Clinical Laboratory Techniques methods
Drug Monitoring methods
Histoplasma immunology
Histoplasmosis diagnosis

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