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Nematodes feel a craving--using Caenorhabditis elegans as a model to study alcohol addiction.
- Source :
-
Neuroscience bulletin [Neurosci Bull] 2014 Aug; Vol. 30 (4), pp. 595-600. Date of Electronic Publication: 2014 Jul 09. - Publication Year :
- 2014
-
Abstract
- Alcohol is the most frequently-used addictive drug. However, the mechanism by which its consumption leads to addiction remains largely elusive. Given the conservation of behavioral reactions to alcohol, Caenorhabitis elegans (C. elegans) has been effectively used as a model system to investigate the relevant molecular targets and pathways mediating these responses. In this article, we review the roles of BK channels (also called SLO-1), the lipid microenvironment, receptors, the synaptic machinery, and neurotransmitters in both the acute and chronic effects of alcohol. We provide an overview of the genes and mechanisms involved in alcoholismrelated behaviors in C. elegans.
- Subjects :
- Animals
Caenorhabditis elegans Proteins metabolism
Large-Conductance Calcium-Activated Potassium Channels metabolism
Lipid Metabolism
Munc18 Proteins metabolism
Receptors, G-Protein-Coupled metabolism
Receptors, Neuropeptide Y metabolism
rab3 GTP-Binding Proteins metabolism
Alcoholism genetics
Alcoholism metabolism
Caenorhabditis elegans
Craving physiology
Disease Models, Animal
Signal Transduction
Subjects
Details
- Language :
- English
- ISSN :
- 1995-8218
- Volume :
- 30
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Neuroscience bulletin
- Publication Type :
- Academic Journal
- Accession number :
- 25008572
- Full Text :
- https://doi.org/10.1007/s12264-014-1451-7