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Maternal/newborn VEGF-C936T interaction and its influence on the risk, severity and prognosis of preeclampsia, as well as on the maternal angiogenic profile.
- Source :
-
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians [J Matern Fetal Neonatal Med] 2014 Nov; Vol. 27 (17), pp. 1754-60. Date of Electronic Publication: 2014 Jul 28. - Publication Year :
- 2014
-
Abstract
- Objective: To analyze the influence of maternal/newborn vascular endothelial growth factor (VEGF)-CT936 interaction as a modulating factor in preeclampsia as well as its influence on the maternal angiogenic balance.<br />Methods: Seventy pairs of preeclamptic women/newborns and 94 pairs of normal pregnant mothers/newborns were genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Serum VEGF and soluble VEGF receptor-1 (sVEGFR-1) levels were measured using ELISA.<br />Results: The risk to develop mild (odds ratio; OR: 3.79, p = 0.008) and severe (OR: 2.94, p = 0.037) preeclampsia being increased in association with the CT936-VEGF genotype and increased in severe preeclampsia to 6.07 (p = 0.03) if the women were carriers of the homozygous TT936-VEGF genotype. The presence of the VEGF-T936 allele in both the mother and the newborn significantly increases the risk of pregnancy-induced hypertension (PIH), mild and severe preeclampsia. If both the mothers and newborns were carriers of the VEGF-T936 allele, significantly lower VEGF and higher sVEGFR-1 levels were observed for all types of preeclampsia. Pregnant women with PIH and severe preeclampsia delivered at a significantly earlier gestational age neonates with a significantly lower birth weight if both the preeclamptic mothers and their newborns were carriers of the VEGF-T936 allele.<br />Conclusions: Our study suggests the role of maternal/fetal VEGF-CT936 polymorphism as a modulating factor in preeclampsia, which affects the angiogenic balance in preeclamptic mothers, as well as their pregnancy outcome.
- Subjects :
- Adult
Cohort Studies
Female
Genetic Predisposition to Disease
Humans
Hypertension, Pregnancy-Induced blood
Hypertension, Pregnancy-Induced diagnosis
Hypertension, Pregnancy-Induced genetics
Infant, Newborn
Pregnancy
Pregnancy Outcome genetics
Prognosis
Risk Factors
Severity of Illness Index
Vascular Endothelial Growth Factor Receptor-1 blood
Young Adult
Maternal-Fetal Relations physiology
Neovascularization, Physiologic genetics
Polymorphism, Single Nucleotide genetics
Pre-Eclampsia blood
Pre-Eclampsia diagnosis
Pre-Eclampsia genetics
Vascular Endothelial Growth Factor A blood
Vascular Endothelial Growth Factor A genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1476-4954
- Volume :
- 27
- Issue :
- 17
- Database :
- MEDLINE
- Journal :
- The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
- Publication Type :
- Academic Journal
- Accession number :
- 25007988
- Full Text :
- https://doi.org/10.3109/14767058.2014.942625