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DEFB1 5'UTR polymorphisms modulate the risk of HIV-1 infection in Mexican women.
- Source :
-
Current HIV research [Curr HIV Res] 2014; Vol. 12 (3), pp. 220-6. - Publication Year :
- 2014
-
Abstract
- Immunologic and genetic factors are involved in HIV-1/AIDS pathogenesis. Defensins are key molecules in innate immunity that participate in the control and/or development of infection and disease. Using PCR-RFLPs, we determined the association between HIV-1/AIDS and human β-defensin 1 (DEFB1) 5'UTR -52 G/A (rs1799946), -44 C/G (rs1800972), and -20 G/A (rs11362) polymorphisms in three groups of women from the state of Sinaloa, located in the Northwest region of Mexico: i) healthy blood donors; ii) sex-workers; and iii) HIV-1 patients. The -52GG genotype was more frequent in blood donors than in patients (p= 0.023; Odds Ratio, OR= 0.49; 95% CI= 0.25-0.95), whereas the - 52GA genotype was significantly higher in patients (p= 0.013; OR= 2.03; 95% CI= 1.11-3.79, statistical power SP= 98.8%), as well as the frequencies of -20A allele (p= 0.017; OR= 1.60; 95% CI= 1.06-2.40), -20AA genotype (p= 0.047; OR = 2.02; 95% CI= 0.93-4.33) and the ACA haplotype with respect to healthy blood donors (p= 0.000012; OR= 5.82; 95% CI= 2.33-16.43, SP= 99.89%) and sex-workers (p= 0.019; OR= 2.18; 95% CI= 1.07-4.46). Conversely, the ACG haplotype was higher in healthy blood donors than in patients (p= 0.009; OR= 0.55; 95% CI= 0.34-0.89). In addition, the -44CC genotype was associated with a low plasma viral load (p= 0.015), whereas AGA, AGG and GGA haplotypes were more prevalent in individuals with high CD4 counts (p= 0.004, 0.046, and 0.029, respectively). These findings associate DEFB1 5'UTR polymorphisms with HIV-1/AIDS in Mexican women for the first time.
- Subjects :
- Adult
Aged
Case-Control Studies
Female
Genotype
HIV Infections immunology
HIV Infections virology
Humans
Mexico
Middle Aged
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length
Risk Assessment
Young Adult
5' Untranslated Regions
Genetic Predisposition to Disease
HIV Infections epidemiology
HIV Infections genetics
HIV-1 isolation & purification
Polymorphism, Genetic
beta-Defensins genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1873-4251
- Volume :
- 12
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Current HIV research
- Publication Type :
- Academic Journal
- Accession number :
- 25001249
- Full Text :
- https://doi.org/10.2174/1570162x12666140708102722