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Parameters of lung inflammation in asthmatic as compared to healthy children in a contaminated city.
- Source :
-
BMC pulmonary medicine [BMC Pulm Med] 2014 Jul 08; Vol. 14, pp. 111. Date of Electronic Publication: 2014 Jul 08. - Publication Year :
- 2014
-
Abstract
- Background: The impact of air pollution on the respiratory system has been estimated on the basis of respiratory symptoms and lung function. However; few studies have compared lung inflammation in healthy and asthmatics children exposed to high levels of air pollution. The aim of the study was to elucidate the modulatory effect of air pollution on Cysteinyl-leukotrienes (Cys-LTs) levels in exhaled breath condensate (EBC) among healthy and asthmatic children.<br />Methods: We performed a cross-sectional comparative study. Children between 7-12 years of age, asthmatics and non-asthmatics, residents of a city with high levels of PM10 were included. In all cases, forced spirometry, Cys-LTs levels in EBC, and the International Study of Asthma and Allergies in Childhood questionnaire were evaluated. We also obtained average of PM10, CO, SO2 and O3 levels during the period of the study by the State Institute of Ecology.<br />Results: We studied 103 children (51 asthmatics and 52 non-asthmatics). Cys-LTs levels were higher in asthmatics than in non-asthmatics (77.3 ± 21.6 versus 60.3 ± 26.8 pg/ml; p = 0.0005). Also, Cys-LTs levels in children with intermittent asthma were lower than in children with persistent asthma (60.4 ± 20.4 versus 84.7 ± 19.2 pg/ml; p = 0.0001). In the multiple regression model, factors associated with levels of Cys-LTs were passive smoking (β = 13.1, p 0.04) and to be asthmatic (β = 11.5, p 0.03).<br />Conclusions: Cys-LTs levels are higher in asthmatic children than in healthy children in a contaminated city and its levels are also associated with passive smoking.
- Subjects :
- Asthma complications
Asthma physiopathology
Breath Tests
Child
Cross-Sectional Studies
Female
Forced Expiratory Volume
Healthy Volunteers
Humans
Leukotriene C4 analysis
Leukotriene D4 analysis
Leukotriene E4 analysis
Male
Pneumonia complications
Spirometry
Surveys and Questionnaires
Tobacco Smoke Pollution
Vital Capacity
Air Pollution
Asthma metabolism
Inflammation Mediators analysis
Particulate Matter
Pneumonia metabolism
Urban Population
Subjects
Details
- Language :
- English
- ISSN :
- 1471-2466
- Volume :
- 14
- Database :
- MEDLINE
- Journal :
- BMC pulmonary medicine
- Publication Type :
- Academic Journal
- Accession number :
- 25000942
- Full Text :
- https://doi.org/10.1186/1471-2466-14-111