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Defining features of protective CD4 T cell responses to Mycobacterium tuberculosis.
- Source :
-
Current opinion in immunology [Curr Opin Immunol] 2014 Aug; Vol. 29, pp. 137-42. - Publication Year :
- 2014
-
Abstract
- CD4 T cells are critical for control of Mycobacterium tuberculosis (Mtb) infection and represent the best hope for vaccine-elicited protection. However, little is understood about the properties of Mtb-specific CD4 T cells that mediate control, and the lack of correlates of protection present a significant barrier to the rational development of new vaccination and therapeutic strategies which are sorely needed. Here we discuss the features of protective CD4 T cells including recent evidence for IFN-γ dependent and independent mechanisms of protection, poor protection by terminally differentiated cells and the importance of T cell migratory capacity for the control of Mtb infection.<br /> (Published by Elsevier Ltd.)
Details
- Language :
- English
- ISSN :
- 1879-0372
- Volume :
- 29
- Database :
- MEDLINE
- Journal :
- Current opinion in immunology
- Publication Type :
- Academic Journal
- Accession number :
- 25000593
- Full Text :
- https://doi.org/10.1016/j.coi.2014.06.003