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Evaluation of circulating irisin levels in healthy young individuals after a single 100,000 IU vitamin D dose.
- Source :
-
Annales d'endocrinologie [Ann Endocrinol (Paris)] 2014 Jul; Vol. 75 (3), pp. 162-4. Date of Electronic Publication: 2014 Jul 02. - Publication Year :
- 2014
-
Abstract
- Irisin is a newly discovered hormone produced by the muscle. This hormone is involved in glucose metabolism, muscle strength and energy expenditure. As vitamin D is also known as a key player in that field, we aimed to see if a single dose of 100,000 IU of vitamin D would modify circulating levels of irisin in 29 young adults. Irisin was determined with the Phoenix Elisa assay at day 0, day 3, day 7 day 15 and day 28 after the loading dose. If we observed a significant increase in 25(OH)D levels (from 19.8±8.4 ng/mL to 33.0±8.5 ng/mL), irisin levels remained constant throughout the study (median 104.5 ng/mL, with values ranging from 69.9 to 390.9 ng/mL). Interestingly, one subject presented irisin values that were three times higher than all the others.<br /> (Copyright © 2014. Published by Elsevier Masson SAS.)
Details
- Language :
- English
- ISSN :
- 2213-3941
- Volume :
- 75
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Annales d'endocrinologie
- Publication Type :
- Academic Journal
- Accession number :
- 24997768
- Full Text :
- https://doi.org/10.1016/j.ando.2014.05.005