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CD4 + primary cutaneous small/medium-sized pleomorphic T-cell lymphoma: a retrospective case series and review of literature.
- Source :
-
Leukemia & lymphoma [Leuk Lymphoma] 2015 Apr; Vol. 56 (4), pp. 951-7. - Publication Year :
- 2015
-
Abstract
- CD4 + primary cutaneous small/medium-sized pleomorphic T-cell lymphoma (CD4 + PCSM-TCL) is a rare T-cell lymphoma associated with a favorable prognosis. A retrospective study of 23 patients with CD4 + PCSM-TCL as defined by World Health Organization-European Organisation for Research and Treatment of Cancer (WHO-EORTC) and WHO classifications was conducted. Median age was 63 years. The head and neck were the most commonly affected locations, followed by the trunk. Two patients had evidence of systemic involvement at relapse. All tumors were CD3 + and CD4+. CD5 and CD7 loss occurred in 52% and 84%, respectively. The median follow-up was 33.6 months. Eleven patients had excisional biopsy only, six had localized radiotherapy and two received excision and localized radiation. Cytotoxic chemotherapy and localized radiation were used in one patient with aggressive and invasive features. All patients had a complete remission but one developed systemic involvement. Our case series demonstrates that CD4 + PCSM-TCL is an indolent T-cell lymphoma that can be treated with local modalities and raises the question of its current classification as a lymphoma.
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Antineoplastic Combined Chemotherapy Protocols therapeutic use
CD4-Positive T-Lymphocytes drug effects
Humans
Lymphoma, T-Cell, Cutaneous drug therapy
Middle Aged
Neoplasm Recurrence, Local
Prognosis
Remission Induction
Retrospective Studies
Skin Neoplasms drug therapy
Treatment Outcome
CD4-Positive T-Lymphocytes pathology
Lymphoma, T-Cell, Cutaneous pathology
Skin Neoplasms pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1029-2403
- Volume :
- 56
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Leukemia & lymphoma
- Publication Type :
- Academic Journal
- Accession number :
- 24996443
- Full Text :
- https://doi.org/10.3109/10428194.2014.938331