Your heart on a chip: iPSC-based modeling of Barth-syndrome-associated cardiomyopathy.

Authors :: Zweigerdt R
Gruh I
Martin U
Source :: Cell stem cell [Cell Stem Cell] 2014 Jul 03; Vol. 15 (1), pp. 9-11.
Publication Year :: 2014
Abstract: Disease-specific induced pluripotent stem cells (iPSCs) are invaluable tools for studying genetic disorders in a dish. A recent paper by Wang et al. (2014) powerfully combines analysis of human iPSCs with genome editing and tissue engineering, in conjunction with biochemical and physiological assays, to provide insights into Barth-syndrome-associated cardiomyopathy.<br /> (Copyright © 2014 Elsevier Inc. All rights reserved.)

Subjects :: Humans
Barth Syndrome physiopathology
Cardiomyopathy, Dilated physiopathology
Induced Pluripotent Stem Cells physiology
Mitochondrial Diseases physiopathology
Models, Biological
Tissue Engineering methods
Transcription Factors genetics

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