Back to Search
Start Over
Rhabdoid Variant of Myoepithelial Carcinoma, with EWSR1 Rearrangement: Expanding the Spectrum of EWSR1-Rearranged Myoepithelial Tumors.
- Source :
-
Head and neck pathology [Head Neck Pathol] 2015 Jun; Vol. 9 (2), pp. 273-9. Date of Electronic Publication: 2014 Jul 04. - Publication Year :
- 2015
-
Abstract
- Myoepithelial and mixed tumors represent a heterogeneous group of neoplasms for which classification is incomplete and continues to evolve. Those arising in the soft tissues appear to represent subgroups that are genetically distinct from those that occur within salivary glands. We describe a case of soft tissue myoepithelial carcinoma with rhabdoid morphology, which presented as an enlarging neck mass in a 40 year old male, and in which EWSR1 rearrangement was demonstrated by fluorescence in situ hybridization. This neoplasm showed diffuse INI1 loss, making distinction from other INI1-negative rhabdoid tumors difficult. This expands the range of reported histologic features of EWSR1-rearranged myoepithelial neoplasms, and highlights the significant morphologic and immunohistochemical overlap between this and other INI1-negative malignant rhabdoid neoplasms.
- Subjects :
- Adult
Biomarkers, Tumor metabolism
Chromosomal Proteins, Non-Histone metabolism
DNA, Neoplasm genetics
DNA-Binding Proteins metabolism
Humans
Male
Myoepithelioma diagnosis
Myoepithelioma surgery
Neck pathology
Neck surgery
RNA-Binding Protein EWS
Rhabdoid Tumor diagnosis
Rhabdoid Tumor surgery
SMARCB1 Protein
Soft Tissue Neoplasms diagnosis
Soft Tissue Neoplasms surgery
Transcription Factors metabolism
Treatment Outcome
Calmodulin-Binding Proteins genetics
Gene Rearrangement genetics
Myoepithelioma genetics
RNA-Binding Proteins genetics
Rhabdoid Tumor genetics
Soft Tissue Neoplasms genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1936-0568
- Volume :
- 9
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Head and neck pathology
- Publication Type :
- Academic Journal
- Accession number :
- 24993038
- Full Text :
- https://doi.org/10.1007/s12105-014-0556-2