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Upstream deregulation of calcium signaling in Parkinson's disease.
- Source :
-
Frontiers in molecular neuroscience [Front Mol Neurosci] 2014 Jun 17; Vol. 7, pp. 53. Date of Electronic Publication: 2014 Jun 17 (Print Publication: 2014). - Publication Year :
- 2014
-
Abstract
- Parkinson's disease (PD) is a major health problem affecting millions of people worldwide. Recent studies provide compelling evidence that altered Ca(2) (+) homeostasis may underlie disease pathomechanism and be an inherent feature of all vulnerable neurons. The downstream effects of altered Ca(2) (+) handling in the distinct subcellular organelles for proper cellular function are beginning to be elucidated. Here, we summarize the evidence that vulnerable neurons may be exposed to homeostatic Ca(2) (+) stress which may determine their selective vulnerability, and suggest how abnormal Ca(2) (+) handling in the distinct intracellular compartments may compromise neuronal health in the context of aging, environmental, and genetic stress. Gaining a better understanding of the varied effects of Ca(2) (+) dyshomeostasis may allow novel combinatorial therapeutic strategies to slow PD progression.
Details
- Language :
- English
- ISSN :
- 1662-5099
- Volume :
- 7
- Database :
- MEDLINE
- Journal :
- Frontiers in molecular neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- 24987329
- Full Text :
- https://doi.org/10.3389/fnmol.2014.00053