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Positive correlations between genomic %AT and genome size within strains of bacterial species.
- Source :
-
Environmental microbiology reports [Environ Microbiol Rep] 2014 Jun; Vol. 6 (3), pp. 278-86. Date of Electronic Publication: 2014 Mar 25. - Publication Year :
- 2014
-
Abstract
- Genomic %AT has been found to correlate negatively with genome size in microbes. While microbes with large genomes are often GC rich and free living, AT-rich bacteria tend to be host associated with smaller genomes. With over 2000 fully sequenced and assembled microbial genomes available, we explored the relationship among genomic %AT, genome size, relative entropy (a measure associated with genetic drift) and fraction of genome islands (GIs) in microbial species with the genomes of more than 10 strains available. A negative correlation with genome size was found in six out of 12 phylogenetic groups and subphyla and a positive correlation in only two. At the species level, we found a trend of positive correlations between genomic %AT and genome size in eight out of 20 species, while only four showed a negative correlation. Estimated chromosomal fractions of GIs were found to correlate positively with genome size in the strains of 14 out of 18 species and genomic %AT in the strains of seven species (two correlated negatively). Although GIs explain most of the observed positive correlations between genomic %AT and size, Chlamydia trachomatis seem to be an exception; therefore, these findings needs to be further explored.<br /> (© 2014 Society for Applied Microbiology and John Wiley & Sons Ltd.)
- Subjects :
- Bacteria genetics
Base Composition
Genome Size
Genome, Bacterial
Subjects
Details
- Language :
- English
- ISSN :
- 1758-2229
- Volume :
- 6
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Environmental microbiology reports
- Publication Type :
- Academic Journal
- Accession number :
- 24983532
- Full Text :
- https://doi.org/10.1111/1758-2229.12145