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Use of pre-treatment 18F-FAMT PET to predict patient survival in squamous cell carcinoma of the esophagus treated by curative surgery.
- Source :
-
Anticancer research [Anticancer Res] 2014 Jul; Vol. 34 (7), pp. 3623-8. - Publication Year :
- 2014
-
Abstract
- Background: [18F]-3-fluoro-alpha-methyl tyrosine (18F-FAMT) as an amino acid tracer in positron emission tomography (PET) has been widely investigated in several tumor types. Herein we investigated the clinical significance of 18F-FAMT PET uptake as a prognostic marker together in our updated data of patients with esophageal cancer.<br />Patients and Methods: We retrospectively assessed the treatment outcomes of 42 patients with histologically-confirmed esophageal cancer. The survival rate was analyzed using the median peak standardized uptake value (SUV) with 2.2 as the cut-off value.<br />Results: FAMT uptakes were significantly correlated with factors reflecting tumor progression. Moreover, a significant correlation was observed between FAMT uptake and disease-free survival (p=0.023). Moreover, on evaluation of individual lymph node groups, the specificity and positive predictive value were significantly higher for 18F-FAMT-PET than for 18F-FDG-PET and computed tomography (CT).<br />Conclusion: 18F-FAMT is an important pre-treatment diagnostic modality and its accumulation is a good predictor of disease-free survival (DFS) in patients with operable esophageal cancer.<br /> (Copyright© 2014 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Carcinoma, Squamous Cell metabolism
Esophageal Neoplasms metabolism
Female
Humans
Lymph Nodes diagnostic imaging
Lymph Nodes pathology
Male
Middle Aged
Multimodal Imaging methods
Positron-Emission Tomography methods
Predictive Value of Tests
Tomography, X-Ray Computed
Carcinoma, Squamous Cell diagnostic imaging
Carcinoma, Squamous Cell surgery
Esophageal Neoplasms diagnostic imaging
Esophageal Neoplasms surgery
Fluorine Radioisotopes
Methyltyrosines pharmacokinetics
Radiopharmaceuticals pharmacokinetics
Subjects
Details
- Language :
- English
- ISSN :
- 1791-7530
- Volume :
- 34
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Anticancer research
- Publication Type :
- Academic Journal
- Accession number :
- 24982378