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The roles of retinoic acid and retinoic acid receptors in inducing epigenetic changes.
- Source :
-
Sub-cellular biochemistry [Subcell Biochem] 2014; Vol. 70, pp. 129-49. - Publication Year :
- 2014
-
Abstract
- Epigenetics is "the branch of biology which studies the causal interactions between genes and their products which bring the phenotype into being" as defined by Conrad Waddington in 1942 in a discussion of the mechanisms of cell differentiation. More than seven decades later we know that these mechanisms include histone tail post-translational modifications, DNA methylation, ATP-dependent chromatin remodeling, and non-coding RNA pathways. Epigenetic modifications are powerful drugs targets, and combined targeting of multiple pathways is expected to significantly advance cancer therapy.
- Subjects :
- Chromatin chemistry
Chromatin metabolism
Chromatin Assembly and Disassembly
DNA Methylation
Histones genetics
Humans
Neoplasms genetics
Neoplasms metabolism
Neoplasms pathology
Protein Binding
Protein Multimerization
RNA, Untranslated genetics
RNA, Untranslated metabolism
Receptors, Retinoic Acid genetics
Retinoid X Receptors genetics
Signal Transduction
Epigenesis, Genetic
Histones metabolism
Protein Processing, Post-Translational
Receptors, Retinoic Acid metabolism
Retinoid X Receptors metabolism
Tretinoin metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0306-0225
- Volume :
- 70
- Database :
- MEDLINE
- Journal :
- Sub-cellular biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 24962884
- Full Text :
- https://doi.org/10.1007/978-94-017-9050-5_7