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Clinical, genomic, and metagenomic characterization of oral tongue squamous cell carcinoma in patients who do not smoke.

Authors :
Li R
Faden DL
Fakhry C
Langelier C
Jiao Y
Wang Y
Wilkerson MD
Pedamallu CS
Old M
Lang J
Loyo M
Ahn SM
Tan M
Gooi Z
Chan J
Richmon J
Wood LD
Hruban RH
Bishop J
Westra WH
Chung CH
Califano J
Gourin CG
Bettegowda C
Meyerson M
Papadopoulos N
Kinzler KW
Vogelstein B
DeRisi JL
Koch WM
Agrawal N
Source :
Head & neck [Head Neck] 2015 Nov; Vol. 37 (11), pp. 1642-9. Date of Electronic Publication: 2014 Aug 23.
Publication Year :
2015

Abstract

Background: Evidence suggests the incidence of oral tongue squamous cell carcinoma is increasing in young patients, many who have no history of tobacco use.<br />Methods: We clinically reviewed 89 patients with oral tongue cancer. Exomic sequencing of tumor DNA from 6 nonsmokers was performed and compared to previously sequenced cases. RNA from 20 tumors was evaluated by massively parallel sequencing to search for potentially oncogenic viruses.<br />Results: Non-smokers (53 of 89) were younger than smokers (36 of 89; mean, 50.4 vs 61.9 years; p < .001), and seemed more likely to be women (58.5% vs 38.9%; p = .069). Nonsmokers had fewer TP53 mutations (p = .02) than smokers. No tumor-associated viruses were detected.<br />Conclusion: The young age of nonsmoking patients with oral tongue cancer and fewer TP53 mutations suggest a viral role in this disease. Our efforts to identify such a virus were unsuccessful. Further studies are warranted to elucidate the drivers of carcinogenesis in these patients.<br /> (© 2014 Wiley Periodicals, Inc.)

Details

Language :
English
ISSN :
1097-0347
Volume :
37
Issue :
11
Database :
MEDLINE
Journal :
Head & neck
Publication Type :
Academic Journal
Accession number :
24954188
Full Text :
https://doi.org/10.1002/hed.23807