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Clinical, genomic, and metagenomic characterization of oral tongue squamous cell carcinoma in patients who do not smoke.
- Source :
-
Head & neck [Head Neck] 2015 Nov; Vol. 37 (11), pp. 1642-9. Date of Electronic Publication: 2014 Aug 23. - Publication Year :
- 2015
-
Abstract
- Background: Evidence suggests the incidence of oral tongue squamous cell carcinoma is increasing in young patients, many who have no history of tobacco use.<br />Methods: We clinically reviewed 89 patients with oral tongue cancer. Exomic sequencing of tumor DNA from 6 nonsmokers was performed and compared to previously sequenced cases. RNA from 20 tumors was evaluated by massively parallel sequencing to search for potentially oncogenic viruses.<br />Results: Non-smokers (53 of 89) were younger than smokers (36 of 89; mean, 50.4 vs 61.9 years; p < .001), and seemed more likely to be women (58.5% vs 38.9%; p = .069). Nonsmokers had fewer TP53 mutations (p = .02) than smokers. No tumor-associated viruses were detected.<br />Conclusion: The young age of nonsmoking patients with oral tongue cancer and fewer TP53 mutations suggest a viral role in this disease. Our efforts to identify such a virus were unsuccessful. Further studies are warranted to elucidate the drivers of carcinogenesis in these patients.<br /> (© 2014 Wiley Periodicals, Inc.)
- Subjects :
- Adult
Age Distribution
Carcinoma, Squamous Cell epidemiology
Carcinoma, Squamous Cell pathology
Cohort Studies
Databases, Factual
Female
Genomics
Humans
Incidence
Male
Metagenome genetics
Middle Aged
Mutation
Neoplasm Invasiveness pathology
Neoplasm Staging
Prognosis
RNA, Messenger genetics
Retrospective Studies
Risk Assessment
Sex Distribution
Smoking
Tongue Neoplasms epidemiology
Carcinoma, Squamous Cell genetics
DNA, Neoplasm genetics
Genetic Predisposition to Disease epidemiology
Tongue Neoplasms genetics
Tongue Neoplasms pathology
Tumor Suppressor Protein p53 genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1097-0347
- Volume :
- 37
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Head & neck
- Publication Type :
- Academic Journal
- Accession number :
- 24954188
- Full Text :
- https://doi.org/10.1002/hed.23807