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Beta-adrenergic responsiveness in stress-sensitive and stress-resistant pigs.
- Source :
-
Journal of veterinary pharmacology and therapeutics [J Vet Pharmacol Ther] 1989 Mar; Vol. 12 (1), pp. 14-8. - Publication Year :
- 1989
-
Abstract
- This study investigated whether enhanced metabolic responsiveness to beta-adrenergic stimulation might explain the liability of the stress-sensitive pig to develop an acidosis during stressful situations. Blood lactate, pH, PCO2 and heart rate response to an intravenous infusion of isoprenaline were examined in three lines of pentobarbitone anaesthetized, atropinized pigs. The lines were Pietrain X Hampshire which had been selected over eight generations for a positive reaction to the halothane test (stress-sensitive); Pietrain X Hampshire which had been selected over eight generations for no reaction to the halothane test (stress-resistant) and British Landrace which had been selected over four generations for a positive halothane reaction (stress-sensitive). The metabolic responses to isoprenaline were greater in the stress-sensitive Pietrain X Hampshire line than the stress-resistant line. The stress-sensitive Landrace pigs, however, had smaller changes in pH and PCO2 in response to isoprenaline than the stress-resistant Pietrain X Hampshire pigs. This inconsistent trend across the three lines led to the conclusion that enhanced beta-adrenergic responsiveness was not the likely cause of stress sensitivity.
- Subjects :
- Animals
Blood Gas Analysis veterinary
Carbon Dioxide blood
Female
Heart Rate drug effects
Hydrogen-Ion Concentration
Infusions, Intravenous
Isoproterenol administration & dosage
Lactates analysis
Lactates blood
Male
Muscles analysis
Stress, Physiological blood
Stress, Physiological physiopathology
Swine
Swine Diseases blood
Isoproterenol pharmacology
Stress, Physiological veterinary
Swine Diseases physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 0140-7783
- Volume :
- 12
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of veterinary pharmacology and therapeutics
- Publication Type :
- Academic Journal
- Accession number :
- 2495369
- Full Text :
- https://doi.org/10.1111/j.1365-2885.1989.tb00635.x