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Quantification of dynamic changes to blood volume and vascular flow in the primate corpus luteum during the menstrual cycle.
- Source :
-
Journal of medical primatology [J Med Primatol] 2014 Dec; Vol. 43 (6), pp. 445-54. Date of Electronic Publication: 2014 Jun 20. - Publication Year :
- 2014
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Abstract
- Background: The objective of the current study was to determine changes to vascular parameters of nonhuman primate dominant ovarian structures by dynamic contrast-enhanced ultrasound (DCE-US).<br />Materials and Methods: Dynamic contrast-enhanced ultrasound with intravenous microbubble infusion was performed on the rhesus macaque ovary bearing the pre-ovulatory follicle and corpus luteum (CL) sequentially during the natural luteal phase (n = 8) and GnRH antagonist (antide)-induced luteal regression (n = 6).<br />Results: Changes in luteal blood volume (BV) and vascular flow (VF) were observed between stages of the luteal phase Luteal BV was highest in early stage CL, before decreasing 2.5-fold in late stage CL (P < 0.06); in contrast, luteal VF peaked at mid luteal stage (P < 0.01). Two females identified with luteal insufficiency trended toward lower peak BV, compared to typical CLs. Another female was identified with a luteal cyst on the contralateral ovary, and a CL that regressed before P levels declined. After 72 hours of antide exposure, BV was reduced 2.3-fold (P = 0.03).<br />Conclusions: DCE-US provides a sensitive, non-invasive measurement of the dynamics of blood volume and flow in dominant ovarian structures.<br /> (© 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
Details
- Language :
- English
- ISSN :
- 1600-0684
- Volume :
- 43
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of medical primatology
- Publication Type :
- Academic Journal
- Accession number :
- 24948037
- Full Text :
- https://doi.org/10.1111/jmp.12132